Lipopolisaccharide treatment leads to down-regulation of cholinergic connections.

2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the role of nitrinergic connections in central cardiovascular responses mediated by physostigmine infused into posterior hypothalamus.

Researchers in Italy report, "In the last few decades, cholinergic connections located in posterior hypothalamus (PH) have been implicated in the central regulation of blood pressure (BP)...[We] investigated the role of nitric oxide (NO) in the blood pressure response elicited by infusion of physostigmine into PH of normotensive rats."

E. Palma and colleagues of the University of Catanzaro explained, "In freely moving rats, physostigmine (60-200 nM) …